What FiO2 level or method is used in initial infant ventilation?

• A. 100%
• B. 10-20%
• C. 40-60% or match
• D. 70-90%

Answer: (C)

The main idea is to provide enough oxygen to support the newborn without causing oxygen toxicity. Starting with 100% oxygen or very high levels can increase risk of oxygen-related injury (like retinopathy of prematurity and pulmonary damage), while very low levels may not meet the infant’s needs. A moderate FiO2 of about 40-60% gives sufficient oxygenation for most infants and allows for careful adjustment. The “or match” approach means titrating the FiO2 to the infant’s actual oxygen needs based on oxygen saturation targets, rather than sticking to a fixed percent. This balances adequate oxygen delivery with minimizing exposure to high oxygen concentrations.